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metabolites  (MedChemExpress)


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    Structured Review

    MedChemExpress metabolites
    Metabolites, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/metabolites/product/MedChemExpress
    Average 94 stars, based on 3 article reviews
    metabolites - by Bioz Stars, 2026-02
    94/100 stars

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    Effects of LPM3770277 on lysosome. (A) : The effect of LPM3770277, LPM3770277, LPM3770277 and lysosomal inhibitor Bafilomycin A1 (25 nM) in combination on HCC1806 and SUM159 cells. (B) : The concentration of the drug contained in the lysosome of HCC1806 cells. (C) : The effects of <t>Abemaciclib</t> and compound 277 on autophagy-related proteins LC3B, P62, LAMP2.
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    Effects of LPM3770277 on lysosome. (A) : The effect of LPM3770277, LPM3770277, LPM3770277 and lysosomal inhibitor Bafilomycin A1 (25 nM) in combination on HCC1806 and SUM159 cells. (B) : The concentration of the drug contained in the lysosome of HCC1806 cells. (C) : The effects of Abemaciclib and compound 277 on autophagy-related proteins LC3B, P62, LAMP2.

    Journal: Frontiers in Pharmacology

    Article Title: LPM3770277, a Potent Novel CDK4/6 Degrader, Exerts Antitumor Effect Against Triple-Negative Breast Cancer

    doi: 10.3389/fphar.2022.853993

    Figure Lengend Snippet: Effects of LPM3770277 on lysosome. (A) : The effect of LPM3770277, LPM3770277, LPM3770277 and lysosomal inhibitor Bafilomycin A1 (25 nM) in combination on HCC1806 and SUM159 cells. (B) : The concentration of the drug contained in the lysosome of HCC1806 cells. (C) : The effects of Abemaciclib and compound 277 on autophagy-related proteins LC3B, P62, LAMP2.

    Article Snippet: Abemaciclib and Abemaciclib metabolite M2 were purchased from MedChemExpress (Monmouth Junction, NJ, United States, LY-2835219, LSN2839567).

    Techniques: Concentration Assay

    The effect of different concentrations of Abemaciclib and compound LPM3770277 on the cell cyle of HCC1806. * p < 0.05 vs. control Two-way ANOVA with a post-hoc Bonferroni test was used for all the statistical analyses. Abem: Abemaciclib, 277: LPM3770277.

    Journal: Frontiers in Pharmacology

    Article Title: LPM3770277, a Potent Novel CDK4/6 Degrader, Exerts Antitumor Effect Against Triple-Negative Breast Cancer

    doi: 10.3389/fphar.2022.853993

    Figure Lengend Snippet: The effect of different concentrations of Abemaciclib and compound LPM3770277 on the cell cyle of HCC1806. * p < 0.05 vs. control Two-way ANOVA with a post-hoc Bonferroni test was used for all the statistical analyses. Abem: Abemaciclib, 277: LPM3770277.

    Article Snippet: Abemaciclib and Abemaciclib metabolite M2 were purchased from MedChemExpress (Monmouth Junction, NJ, United States, LY-2835219, LSN2839567).

    Techniques: Control

    Results of xenograft tumor model of Abemaciclib and LPM3770277 in HCC1806 and SUM159 cells. (A,D) : Tumor volume. (B,E) : Tumor weight. (C,F) : Bodyweight were measured. * p < 0.01 vs. control, *** p < 0.001 vs. control, ## p < 0.01 vs. LPM3770277, Two-way ANOVA with a post-hoc Bonferroni test was used for all the statistical analyses.

    Journal: Frontiers in Pharmacology

    Article Title: LPM3770277, a Potent Novel CDK4/6 Degrader, Exerts Antitumor Effect Against Triple-Negative Breast Cancer

    doi: 10.3389/fphar.2022.853993

    Figure Lengend Snippet: Results of xenograft tumor model of Abemaciclib and LPM3770277 in HCC1806 and SUM159 cells. (A,D) : Tumor volume. (B,E) : Tumor weight. (C,F) : Bodyweight were measured. * p < 0.01 vs. control, *** p < 0.001 vs. control, ## p < 0.01 vs. LPM3770277, Two-way ANOVA with a post-hoc Bonferroni test was used for all the statistical analyses.

    Article Snippet: Abemaciclib and Abemaciclib metabolite M2 were purchased from MedChemExpress (Monmouth Junction, NJ, United States, LY-2835219, LSN2839567).

    Techniques: Control

    Effects of Abemaciclib and LPM3770277 on the blood of nude mice. HFR%, High fluorescence intensity reticulocyte percentage; IRF, Immature reticulocyte fraction; LFR%, Low fluorescence intensity reticulocyte percentage; MRF%, Medium fluorescence intensity reticulocyte percentage; WBC, White blood cell; LYMPH#, Lymphocyte-count; NEUT#, Neutrophil count; EO%, Percentage of basophils; MONO%, Percentage of Monocyte; MONO#, Monocyte count. * p ˂ 0.05 vs. control, ** p ˂ 0.01 vs. control, One-way ANOVA with a post-hoc Bonferroni test was used for all the statistical analysis.

    Journal: Frontiers in Pharmacology

    Article Title: LPM3770277, a Potent Novel CDK4/6 Degrader, Exerts Antitumor Effect Against Triple-Negative Breast Cancer

    doi: 10.3389/fphar.2022.853993

    Figure Lengend Snippet: Effects of Abemaciclib and LPM3770277 on the blood of nude mice. HFR%, High fluorescence intensity reticulocyte percentage; IRF, Immature reticulocyte fraction; LFR%, Low fluorescence intensity reticulocyte percentage; MRF%, Medium fluorescence intensity reticulocyte percentage; WBC, White blood cell; LYMPH#, Lymphocyte-count; NEUT#, Neutrophil count; EO%, Percentage of basophils; MONO%, Percentage of Monocyte; MONO#, Monocyte count. * p ˂ 0.05 vs. control, ** p ˂ 0.01 vs. control, One-way ANOVA with a post-hoc Bonferroni test was used for all the statistical analysis.

    Article Snippet: Abemaciclib and Abemaciclib metabolite M2 were purchased from MedChemExpress (Monmouth Junction, NJ, United States, LY-2835219, LSN2839567).

    Techniques: Fluorescence, Control